Endocrine Abstracts

Objective: Thyroglobulin (Tg) production by normal or malignant thyroidal cells is TSH dependent. The rhTSH administration for Tg stimulation in patients with differentiated thyroid cancer (DTC), after thyroidectomy and eradication of thyroid remnants with I-131, offers an alternative to thyroid hormone withdrawal preventing the progressive morbidity of hypothyroidism. Tg measurement is usually obtained on the 3rd and 5th day after the first rhTSH injection.<p class="abste...

Introduction: Among all thyroid nodules 3 to 10% are Hürthle cell (HC) neoplasms classified as either HC adenomas or carcinomas. The presence of capsular or vascular invasion is indicative of a HC carcinoma whose incidence has been found to be 5 to 35%. Hürthle cell carcinoma could also lead to distant metastases and its decreased ability to uptake radioiodine worsens the prognosis. There are reports of histologically characterized HC adenomas with unpredictable clin...

Introduction: Most cases of Diabetes mellitus (DM) in children and adolescents are autoimmune (type 1), even though recently there has been an increase in type 2 DM mainly due to the increased prevalence of obesity in this age group. However, rarely DM could be attributed to other causes such as MODY. An extremely rare cause is the hereditary pancreatitis due to activating mutations of the PRSS1 gene. This gene encodes an enzyme, cationic trypsinogen, whose hyperactivity leads...

Forty-one vitamin D deficient women (aged 26-75 years, mean 56.2, median 57) were treated with Vitamin D3 (50000 IU/week for 1.5 month and 25000 IU/week for another 1.5 month). Before treatment their serum 25(OH)D was 17.3&pm;6.1 ng/ml (mean&pm;SD) and after treatment 37.0&pm;7.5 (P<0.0001). Their HOMA-IR was 2.2&pm;1.1 before and 2.3&pm;1.1 after (P=NS), serum insulin 9.0&pm;4.2 mIU/l before and 9.6&pm;4.5 after (NS), glucose 96.2&pm;8.2 mg/dl before and...

Introduction: The clinical profile of patients with primary hyperparathyroidism has changed significantly in the last decades considering the fact that most cases are asymptomatic. This could be attributed to early diagnosis due to routinely serum calcium measurement. Only 5–27% of patients present with symptoms or signs related to osteoporosis, nephrolithiasis and hypercalcaemia. However, in patients with asymptomatic primary hyperparathyroidism (APHP) data concerning t...